Table of Contents
June 20, 2002
Volume 45, Issue 13
Pages 5-2886
p 5
Publication Date (Web): June 13, 2002 (Editorial)
DOI: 10.1021/jm020181a
Hi-Res PDF[7K]
Articles
Structural Differences of Matrix Metalloproteinases with Potential Implications for Inhibitor Selectivity Examined by the GRID/CPCA Approach
Gitte Elgaard Terp, Gabriele Cruciani, Inge Thøger Christensen, and Flemming Steen Jørgensen
pp 2675–2684Publication Date (Web): May 16, 2002 (Article)
DOI: 10.1021/jm0109053
Suitability of Molecular Descriptors for Database Mining. A Comparative Analysis
Gabriele Cruciani, Manuel Pastor, and Raimund Mannhold
pp 2685–2694Publication Date (Web): May 24, 2002 (Article)
DOI: 10.1021/jm0011326
Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain
Xiaohui Du, Chun Guo, Elizabeth Hansell, Patricia S. Doyle, Conor R. Caffrey, Tod P. Holler, James H. McKerrow, and Fred E. Cohen
pp 2695–2707Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm010459j
Synthesis and Structure−Activity Relationships of Amide and Hydrazide Analogues of the Cannabinoid CB1 Receptor Antagonist N-(Piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)
Ma. Elena Y. Francisco, Herbert H. Seltzman, Anne F. Gilliam, René A. Mitchell, Sharyl L. Rider, Roger G. Pertwee, Lesley A. Stevenson, and Brian F. Thomas
pp 2708–2719Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm010498v
Antifungal Agents. 10. New Derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, Synthesis, Anti-Candida Activity, and Quantitative Structure−Analysis Relationship Studies
Andrea Tafi, Roberta Costi, Maurizio Botta, Roberto Di Santo, Federico Corelli, Silvio Massa, Andrea Ciacci, Fabrizio Manetti, and Marino Artico
pp 2720–2732Publication Date (Web): May 29, 2002 (Article)
DOI: 10.1021/jm011087h
From Imidazoles to Pyrimidines: New Inhibitors of Cytokine Release
Stefan A. Laufer and Gerd K. Wagner
pp 2733–2740Publication Date (Web): May 17, 2002 (Article)
DOI: 10.1021/jm011098a
Design, Synthesis, and Evaluation of New Chemosensitizers in Multi-Drug-Resistant Plasmodium falciparum
Jian Guan, Dennis E. Kyle, Lucia Gerena, Quan Zhang, Wilbur K. Milhous, and Ai J. Lin
pp 2741–2748Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm010549o
Design and Quantitative Structure−Activity Relationship of 3-Amidinobenzyl-1H-indole-2-carboxamides as Potent, Nonchiral, and Selective Inhibitors of Blood Coagulation Factor Xa
Hans Matter, Elisabeth Defossa, Uwe Heinelt, Peter-Michael Blohm, Detlev Schneider, Andrea Müller, Silke Herok, Herman Schreuder, Alexander Liesum, Volker Brachvogel, Petra Lönze, Armin Walser, Fahad Al-Obeidi, and Peter Wildgoose
pp 2749–2769Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm0111346
SMall Molecule Growth 2001 (SMoG2001): An Improved Knowledge-Based Scoring Function for Protein−Ligand Interactions
Alexey V. Ishchenko and Eugene I. Shakhnovich
pp 2770–2780Publication Date (Web): May 14, 2002 (Article)
DOI: 10.1021/jm0105833
Synthesis and Biological Evaluation of Analogues of the Peptaibol Ampullosporin A
Hoai-Huong Nguyen, Diana Imhof, Matthias Kronen, Brigitte Schlegel, Albert Härtl, Udo Gräfe, Lajos Gera, and Siegmund Reissmann
pp 2781–2787Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm0208018
Synthesis and Structure−Affinity−Activity Relationships of Novel Benzofuran Derivatives as MT2 Melatonin Receptor Selective Ligands
Valérie Wallez, Sophie Durieux-Poissonnier, Philippe Chavatte, Jean A. Boutin, Valérie Audinot, Jean-Paul Nicolas, Caroline Bennejean, Philippe Delagrange, Pierre Renard, and Daniel Lesieur
pp 2788–2800Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm0005252
Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the Mouse Melanocortin Receptors. 1. Modifications at the His Position
Jerry Ryan Holder, Rayna M. Bauzo, Zhimin Xiang, and Carrie Haskell-Luevano
pp 2801–2810Publication Date (Web): May 24, 2002 (Article)
DOI: 10.1021/jm0104872
Quantitative Structure−Activity Relationship Analysis of Functionalized Amino Acid Anticonvulsant Agents Using k Nearest Neighbor and Simulated Annealing PLS Methods
Min Shen, Arnaud LeTiran, Yunde Xiao, Alexander Golbraikh, Harold Kohn, and Alexander Tropsha
pp 2811–2823Publication Date (Web): May 30, 2002 (Article)
DOI: 10.1021/jm010488u
N-Substituted 4-Amino-3,3-dipropyl-2(3H)-furanones: New Positive Allosteric Modulators of the GABAA Receptor Sharing Electrophysiological Properties with the Anticonvulsant Loreclezole
Ahmed El Hadri, Ahmed Abouabdellah, Urs Thomet, Roland Baur, Roman Furtmüller, Erwin Sigel, Werner Sieghart, and Robert H. Dodd
pp 2824–2831Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm011082k
Structural Features of Azidopyridinyl Neonicotinoid Probes Conferring High Affinity and Selectivity for Mammalian α4β2 and Drosophila Nicotinic Receptors
Nanjing Zhang, Motohiro Tomizawa, and John E. Casida
pp 2832–2840Publication Date (Web): May 25, 2002 (Article)
DOI: 10.1021/jm010508s
Synthesis and Evaluation of a Novel Series of 2-Chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine Analogues as Potential Positron Emission Tomography Imaging Agents for Nicotinic Acetylcholine Receptors
LaVerne L. Brown, Santosh Kulkarni, Olga A. Pavlova, Andrei O. Koren, Alexey G. Mukhin, Amy H. Newman, and Andrew G. Horti
pp 2841–2849Publication Date (Web): May 29, 2002 (Article)
DOI: 10.1021/jm010550n
Acylating Agents as Enzyme Inhibitors and Understanding Their Reactivity for Drug Design
Nicholas O. Sykes, Simon J. F. Macdonald, and Michael I. Page
pp 2850–2856Publication Date (Web): May 24, 2002 (Article)
DOI: 10.1021/jm0111245
Structure−Activity Relationship for Enhancement of Paracellular Permeability across Caco-2 Cell Monolayers by 3-Alkylamido-2-alkoxypropylphosphocholines
Hui Ouyang, Susan L. Morris-Natschke, Khalid S. Ishaq, Peter Ward, Dongzhou Liu, Sarah Leonard, and Dhiren R. Thakker
pp 2857–2866Publication Date (Web): May 25, 2002 (Article)
DOI: 10.1021/jm020001x
Prediction of Volume of Distribution Values in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data
Franco Lombardo, R. Scott Obach, Marina Y. Shalaeva, and Feng Gao
pp 2867–2876Publication Date (Web): May 21, 2002 (Article)
DOI: 10.1021/jm0200409
Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors
Soon Hyung Woo, Sylvie Frechette, Elie Abou Khalil, Giliane Bouchain, Arkadii Vaisburg, Naomy Bernstein, Oscar Moradei, Silvana Leit, Martin Allan, Marielle Fournel, Marie-Claude Trachy-Bourget, Zuomei Li, Jeffrey M. Besterman, and Daniel Delorme
pp 2877–2885Publication Date (Web): May 18, 2002 (Article)
DOI: 10.1021/jm020154k
Book Reviews
Handbook of Drug Screening. Volume 114. Drugs and the Pharmaceutical Sciences Edited by Ramakrishna Seethala and Rabhavathi B. Fernandes. Marcel Dekker, Inc., New York. 2001. xiii + 597 pp. 16 × 24 cm. ISBN 0-8247-0562-9. $195.00.
Greg T. Hermanson
p 2886Publication Date (Web): May 24, 2002 (Book Review)
DOI: 10.1021/jm020185f